Welcome to the riboCIRC database

Translation of circular RNAs (circRNAs) now has drawn increasing attention from researchers due to their emerging roles of the functional peptides encoded by circRNAs as new players involved in the regulation of gene expression. However, the scope of circRNA translation is not yet clear. To this end, we analyzed 3,168 publicly available Ribo-seq datasets and 1,970 matched RNA-seq datasets from the same samples involving 314 studies covering 21 species to determine the prevalence of circRNA translation, and developed a translatome data-oriented circRNA database named riboCIRC, which aims to provide: (1) a comprehensive repository of computationally predicted ribosome-associated circRNAs (Ribo-circRNAs), together with multiple lines of evidence further supporting their translation, including cORF, IRES, m6A and mass spectrometric proofs; (2) a manually curated collection of experimentally verified translated circRNAs; (3) an evaluation of cross-species conservation of translatable circRNAs; (4) a systematic de novo annotation of putative circRNA-encoded peptides, including sequence, structure, and function, and (5) a genome browser to visualize the context-specific occupant footprints of circRNAs.


Currently the database contains a total of 0 computationally predicted ribo-circRNAs across 0 different species (Human, Mouse, Rat, C.elegans, Drosophila and Zebrafish) and 0 literature-reported coding circRNAs.



News

  • 3 Apr 2025

    riboCIRC v2.0 will be accessible.

  • 8 Mar 2021

    riboCIRC is published in Genome Biology.

  • 15 Aug 2020

    riboCIRC v1.0 is released.


Citation

  • Please cite our work when using this resource in your publications:
  • Li, H., Xie, M., Wang, Y. et al. riboCIRC: a comprehensive database of translatable circRNAs. Genome Biol. 2021 Mar 8;22(1):79. doi: 10.1186/s13059-021-02300-7.

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